Pseudogenes are abundant in the human genome and had long been thought of purely as nonfunctional gene fossils.Recent observations point to a role for pseudogenes in regulating genes transcriptionally and post-transcriptionally in human cells.To computationally interrogate the network space of integrated pseudogene and long non-coding RNA regulatio
The U.S.Geological Survey National Earthquake Information Center leads real-time efforts to provide rapid and accurate assessments of the impacts of global earthquakes, including estimates of ground shaking, ground failure, and the resulting human impacts.These efforts primarily rely on analysis of the seismic wavefield to characterize the source o
Ruminants are foregut fermenters that have the remarkable ability aboriginal flag beanie of converting plant polymers that are indigestible to humans into assimilable comestibles like meat and milk, which are cornerstones of human nutrition.Ruminants establish a symbiotic relationship with their microbiome, and the latter is the workhorse of carboh
Objectives: We previously found that the pluripotency factor OCT4 is reactivated in smooth muscle cells (SMC) in human and mouse atherosclerotic plaques and plays an atheroprotective role.Loss of OCT4 in SMC in vitro was associated with decreases in SMC migration.However, molecular mechanisms responsible for atheroprotective SMC-OCT4-dependent effe